Oxytocin receptor antagonists for inhibiting preterm labour
نویسندگان
چکیده
منابع مشابه
Prophylactic antibiotics for inhibiting preterm labour with intact membranes.
BACKGROUND The aetiology of preterm birth is complex and there is evidence that subclinical genital tract infection influences preterm labour in some women but the role of prophylactic antibiotic treatment in the management of preterm labour is controversial. Since rupture of the membranes is an important factor in the progression of preterm labour, it is important to see if the routine adminis...
متن کاملBarusiban suppresses oxytocin-induced preterm labour in non-human primates
BACKGROUND Preterm labour (PTL) is a major cause of neonatal mortality and morbidity, and oxytocin (OT) antagonists are potential tocolytics. Atosiban (TRACTOCILE) is a mixed vasopressin V1A/OT antagonist registered for acute treatment of PTL in Europe. Other off-label drugs have serious side effects. Barusiban is a selective OT antagonist which has reached clinical development. A monkey model ...
متن کاملVasopressin and oxytocin in normal reproduction and in the pathophysiology of preterm labour and primary dysmenorrhoea. Development of receptor antagonists for therapeutic use in these conditions.
Vasopressin and oxytocin are synthesised in the hypothalamus and released to the blood stream via the posterior lobe of the hypophysis. Research during later years has shown that these peptides are also produced in other parts of the brain. The secretion to plasma is stimulated by oestrogen, an effect which is counteracted by progestagen. During delivery the fetus can also produce substantial a...
متن کاملOxytocin and carbetocin effects on spontaneous behavior of male rats: modulation by oxytocin receptor antagonists.
OBJECTIVES Oxytocin (OXY) in addition to peripheral actions has many central regulatory functions which can be studied on animal models. In the present study we examined in rats, which behavioral actions of OXY and long-acting carba-analog of OXY carbetocin (CBT) in the open-field can be inhibited by OXY-receptor antagonists. Our interest focused on the behavioral patterns considered indicative...
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ژورنال
عنوان ژورنال: Cochrane Database of Systematic Reviews
سال: 2014
ISSN: 1465-1858
DOI: 10.1002/14651858.cd004452.pub3